纤维蛋白原基因G(-455)A多态性与缺血性脑卒中的关系

Association of fibrinogen gene G(-455)A polymorphism with ischemic stroke

目的 探讨缺血性脑卒中与纤维蛋白原基因G( 45 5 )A多态性的关系。方法 利用PCR技术和分子杂交技术对北京地区 2 94例缺血性脑卒中患者进行纤维蛋白原基因G( 45 5 )A多态性位点的检测和分析 ,并与 2 79例北京地区的非脑卒中患者进行比较。结果 缺血性脑卒中患者纤维蛋白原基因G( 45 5 )A多态性的基因型频率和等位基因频率与对照组相比无明显差异。结论 纤维蛋白原基因G( 45 5 )A多态性可能不是缺血性脑卒中发病的遗传学危险因素。

Objective To explore the relationship between G( 455)A polymorphism of fibrinogen gene and ischemic stroke.Methods Fibrinogen gene G( 455)A polymorphism was determined by polymerase chain reaction (PCR) and molecular hybridization in 294 cases of ischemic stroke and 279 controls selected from Beijing population.The two groups were matched in sex,age and blood pressure.Results The prevalence rates of genotype frequency and allele frequency of G( 455)A polymorphism of fibrinogen gene were not significantly different between ischemic stroke cases and controls (P>0.05).Conclusion There is no association between fibrinogen gene G( 455)A polymorphism with ischemic stroke.