补阳还五汤及拆方对血栓形成大鼠梗塞灶、血管损伤半暗区、血浆t-PA、PAI活性及ET含量的影响

Effect of BuYanHanWu (BYHW)Tang upon Infarction,Vessel Damage Penumbra(VDP), Fibrinolytic System Activity and Endothelin

利用已建立的冷光源光化学诱导血栓形成大鼠动物模型 ,观察补阳还五汤总方、补气药及活血药对模型大鼠梗塞面积、血管损伤半暗带面积及程度、局部脑组织血流、血浆t PA、PAI活性及血浆ET含量的影响。结果 :补阳还五汤总方对上述指标均有显著性影响 ,补气药及活血药均可缩小梗塞面积 ,减轻血管损伤程度 ,改善梗塞区上游供血区脑组织血流 ,抑制血浆PAI活性。活血药可显著降低血浆ET含量 ;补气药可显著地提高血浆t PA活性 。

Objective:To investigate the effect of BuYanHanWu (BYHW) Tang upon infarction,vessel damage penumbra (VDP),fibrinolytic system activity and endothelin.Methods:BYHW Tang consists of two parts,invigorationg Qi section (IQs) and promoting blood flow section (PBFs).To utilize the model of cold photochemical initiation of thrombosis to observe the effects of the whole of BYHW Tang,IQs and PBFs,respectively,on infarction size,VDP size,degree of vessel damage,localized cerebral blood flow,plasma tissue plasminogen activator( t \|PA),plasminogen activator in hibitor (PAI) and plasma endothelin content.Result:BYHW Tang influences all indexes significantly.IQs and PBFs both have the actions of limiting infarction size and degree of vessel damage,promoting of cerebral blood flow and inhibiting PAI activity.On the other hand,reducing the size of VDP and increasing the activity of t PA by BYHW Tang come mainly from IQs,and the effect of reducing ET content is based on PBFs.Conclusion:The IQs is emphasized in the priscription of BYHW Tang.It can enhance the activity of fibrinolytic system and reduce the VIP size.The result hints BYHQ Tang is not only formulated for stroke caused by deficiency of Qi,but also effective for the treatment of ischemic stroke.