养心康对心功能不全动物模型的血流动力学研究

Hemodynamic Study of Yangxinkang

目的 :建立心功能不全的动物模型 ,探讨养心康在血流动力学方面的作用及其作用机理。方法 :通过增加腹主动脉压力负荷而建立心功能不全的兔模型 ,以高、低两种不同剂量的养心康治疗 2 0d ,以心宝作为药物对照 ,并设立模型对照和空白对照 ,观察各组模型血流动力学指标及血液中一氧化氮水平在治疗前后的变化。结果 :大剂量养心康能明显降低心衰模型的心率、收缩压、左室舒张末压 (LVEDP) ,心室等容收缩期中室内压上升的最大速率 ( +dp/dtmax)及心室等容舒张期中室内压下降的最大速率 ( -dp/dtmax) ,且呈剂量依赖性 ,与心宝对照组相比具有显著性差异。结论 :养心康能剂量依赖性地改善心衰模型的血流动力学指标 ,延缓心衰的进程 。

Objective:To observe the effects of Yangxinkang on hemodynamic indexes of heart failure (HF) in rabbits and to study its possible mechanism.Methods:The HF rabbit model was established by increasing the pressure load on abdominal aorta.Rabbits receiving high and low dosages of Yangxinkang served as the treatment groups,others receiving Xinbao as the positive control group.Model control group and blank control group were also set up.Indexes such as heart rate(HR),systolic blood pressure(SBP),left ventricular end-diastolic pressure(LVEDP)and ±dp/dt max were observed.The level of nitric oxide(NO)was also measured.Results:High dosage of Yangxinkang could decrease HR,SBP and LVEDP,and improve±dp/dt max at the same time,the effects being dose-dependent.The differences were significant as compared with Xinbao group(P<0.01 or P<0.05).Conclusion:Yangxinkang can improve the cardiac function of the HF model, delay the process of HF. Its mechanism is probably related to the decrease of serum NO level.