牛黄千金散抗炎镇痛和免疫抑制作用

Anti-inflammatory, Analgesic and Immunosuppressive Action of Niuhuang Qianjin San

目的 :通过对牛黄千金散的消炎、镇痛、免疫抑制作用的研究 ,探讨牛黄千金散的药理作用 ,为临床应用提供理论依据。方法 :抗炎作用应用大白鼠足趾肿胀法、小白鼠耳廓肿胀法 ;镇痛作用运用小白鼠扭体法、大白鼠钾离子皮下透入致痛法 ;免疫抑制作用 ,测定外周血T淋巴细胞百分率、小白鼠脾淋巴细胞转化率、巨噬细胞吞噬功能、迟发性变态反应 (DTH)、血清溶血素和抗体形成细胞的功能。结果 :牛黄千金散有明显的抗炎作用 ,并能加强可待因的镇痛作用及免疫抑制作用 ,与生理盐水对照组比较有非常显著性差异。结论 :牛黄千金散有抗炎。

Objective: To study the anti-inflammatory, analgesic and immunosuppressive action of Niuhuang Qianjin San (NQS). Methods: The anti-inflammatory action of NQS was studied by the methods of rat paw swelling and mouse ear swelling and the analgesic action by mouse body torsion method and K + subcutaneous penetration method in rats.Immunosuppressive effect was evaluated by peripheral T lymphocyte percentage, splenic lymphocyte transformation ratio, phagocytic function of intraperitoneal magocytes, the activity of delayed hypersensitivity, serum hemolysin level and the function of antibody-yielding cells in mice. Results: NQS could obviously alleviate inflammation, increase codeine's analgesic action and suppress immunity. The difference were significant (P<0.01) as compared with normal saline control group.Conclusion:NQS exerts certain anti-inflammatory,analagisic and immunosuppressive action.