工娱疗合并舒必利治疗精神分裂症阴性症状的对照研究

A controlled study of the negative symptoms of schizophrenia treated by sulpiride combined with occupational and recreational therapy.

目的 探讨工娱疗合并舒必利对精神分裂症阴性症状的治疗康复作用。方法 将60例以阴性症状为主的精神分裂症患者随机分成两组,进行为期8周的对照研究,分别用工娱疗合并舒必利(研究组)和舒必利(对照组)治疗;采用 BPRS、SANS、SAPS和临床疗效评定标准进行评定。结果 研究组在治疗后4周、8周末SANS评分较治疗前均有显著性差异。对照组仅在治疗后8周时SANS评分较疗前有显著性差异。两组在治疗后4周,8周时SANS减分均数比较均有非常显著性差异(P<0.01)。结论 工娱疗合并舒必利对精神分裂症阴性症状的疗效优于单用舒必利,且起效快。

Objective To investigate the effect of sulpiride combined with occupational and recreational therapy on the negative symptoms of schizophrenia. Method 60 schizophrenic patients with mainly negative symptoms were randomly divided into study group and control group for 8 weeks controlled study. Study group was treated by sulpiride combined with occupational and recreational therapy while control group just by sulpiride. The clinical effect was evaluated with BPRS, SANS and SAPS. Result In study group, the score of SANS significantly decreased at both the end of 4th week and 8th week after treatment,but in control group, the score of SANS significantly decreased only at the end of 8th week. There were significant differences in the decreased score of SANS between two groups at both the end of 4th week and 8th week.Conclusions Combined therapy was better than just sulpiride.