摘要
目的 :观察鼻腔应用布地奈德治疗对鼻息肉中 IL - 5表达的影响 ,深入了解糖皮质激素类药物局部治疗对鼻息肉的作用机制。方法 :采用免疫组化 ABC法 ,观察经布地奈德治疗 6～ 8周和未经治疗的鼻息肉组织 (各 16例 )中 ,IL -5阳性细胞的浸润和分布状况。结果 :鼻息肉组织固有层中可见 IL - 5阳性细胞表达 ,且多为嗜酸性粒细胞 ,IL - 5阳性细胞密度与嗜酸性粒细胞的浸润程度密切相关 (y=14.782 + 2 .0 0 2 x,r=0 .6 48,P <0 .0 1)。经布地奈德治疗的鼻息肉组织中 IL - 5阳性细胞的浸润程度有下降的趋势 ,但与未治组织的差异未达显著性水平 (P >0 .0 5 )。结论 :1IL - 5的表达与嗜酸性粒细胞的浸润密切相关 ,嗜酸性粒细胞是鼻息肉组织中 IL- 5的来源之一 ;2鼻腔应用布地奈德 6～ 8周治疗可能抑制鼻息肉中 IL- 5表达。
Objective:To assess the effects of intranasal cortisteroids application on IL 5 expression in nasal polyps.Methods:Nasal polyps from topical nasal steroid treated patients (n=16) and untreated patients (n=16) were investigated.The specimens were stained by ABC immunohistochemical approach.Results:Most of the IL 5 positive cells were eosinophils,and there was a significant correlation of the mean IL 5 positive cell numbers with total (chromotrope 2R positive) eosinophil numbers (y=14 782+2 002x,r=0 648,P<0 01).Compared with untreated polyps,the steroid treated polyps contained a slightly lower tissue density of IL 5 positive cells,and the difference was not statistically significant.Conclusions:Eosinophils are one of the origins of IL 5 synthesis.The treatment used here was insufficient to affect IL 5 expression in nasal polyps.
出处
《耳鼻咽喉（头颈外科）》
2001年第1期35-37,共3页
Chinese Arch Otolaryngology-Head Neck Surg
