检测血管紧张素转化酶在AFP阴性肝癌诊断中的价值

The Serum Activity of Angiotensin converting Enzyme in Diagnosis of AFP negtive HCC Patients

目的 探讨肝癌患者血清血管紧张素转化酶 (ACE)活性变化对AFP阴性肝癌 (HCC)患者诊断及鉴别诊断的价值。方法 选择经组织学 (肝穿刺 )或影像学确诊的 38例HCC患者 ,2 1例慢性肝炎患者 ,12例肝硬化患者及 2 0例正常健康对照者 ,检测血清AFP含量和ACE活性。结果 与其他良性肝病相比HCC患者血清ACE活性 ( 19.51± 4 .4 6)显著低于慢性肝炎 ( 38.35± 6.34 ,P <0 .0 1)及肝硬化患者 ( 4 7.77± 10 .59,P <0 .0 1) ,并且也低于正常人 ( 30 .0 0± 2 .92 ,P <0 .0 5)。 2 3例AFP阳性 (≥2 0 0mg/L)HCC患者中 ,其ACE活性为 ( 19.15± 4 .2 6) ,与AFP阴性患者比较差异无显著性 (P >0 .0 5)。结论 检测血清ACE活性有助于肝癌 ,尤其是合并肝硬化或AFP阴性的患者的诊断。

Objective To research the value of serum activity of angiotensin converting enzyme (ACE) in hepatocellular carcinoma.Method The serum activity of ACE had been examined on 38 primary liver carcinoma patients,21 patients with chronic hepatitis,and 20 healthy subjects.Result The serum activity of ACE increased in patients with cirrhosis (47.77±10.59,P<0.01), chronic hepatitis(38.35±6.34,P<0.01)and decreased in hepatocellular carcinoma patients (19.51±4.46),what was statistically significant in comparison with the activity of the same enzyme in healthy subjects (30.00±2.92,P<0.05).there was no difference between AFP positive (≥200mg/L) and AFP negative(<200mg/L) patients.Conclusion These results suggested that measuring serum ACE activity as one of hepatocellular carcinoma marker in differential diagnosis of the liver disease,especially in AFP negative cirrotic patients.