临产后外周血一氧化氮和环磷酸鸟苷水平的变化

Concentrations of Nitric Oxide and cGMP in Maternal Venous Blood during Labor

目的 探讨一氧化氮 (NO)和环磷酸鸟苷 (cGMP)与分娩发动的关系。方法 采用Griess反应及放免法测定临产前后外周血NO和cGMP水平。结果 无宫缩组及宫缩组外周血NO和cGMP水平明显高于对照组 ,P<0 .0 0 1;但无宫缩组与宫缩组相比 ,无显著差异 ,P >0 .0 5。结论 NO的水平与孕期维持子宫静息状态有关 ,与分娩发动无关。

Objective To study the relationship between NO cGMP and labor. Methods Concentrations of nitric oxide(NO) and cGMP in maternal venous blood with labor and without labor were measured by Greiss reaction and radiommunoassay, respectively. Results Concentrations of nitric oxide(NO) and cGMP in maternal venous blood with labor and without labor were higher than those of the control group,there was no difference between the group with labor and the group without labor. Conclusions Nitric oxide(NO) may play a role in the maintenance of uterine quiescence during pregnancy, but not in the onset of labor.