慢性乙型肝炎患者生存质量测量与影响因素分析

Measuring and Assessing the Survival Quality of Patients with Chronic Hepatitis B

目的 测量并评价慢性乙型肝炎患者生存质量 (QOL) ,分析其主要影响因素。方法 采用生存质量SF 36表 ,对 2 0 0例慢性乙型肝炎患者及 2 0 0例正常对照进行生存质量 (QOL)测量 ,并对QOL的影响因素进行单因素分析和多因素逐步回归分析 ,寻找其中主要影响因素。结果 慢性乙型肝炎患者组的SF 36总评分及生理机能、角色生理状况、心理健康状况、社会机能、机体活力、躯体不适和主观健康状况的平均评分与对照组相比显著降低(P <0 .0 1) ;影响慢性乙肝患者QOL的主要因素是病程、并发症、谷丙转氨酶 (ALT)、乏力、黄疸等。结论 慢性乙型肝炎患者的生存质量全面下降 ,有效的治疗以缩短病程、减少并发症及心理治疗和护理将有利于改善患者的生存质量。

Objective To measure and assess the survival quality of patients with chronic hepatitis B.Method The survival quality of 200 patients with chronic hepatitis B and 200 healthy controls were marked by survival quality SF 36,and single and multiple stepwise regression analysis were made to evaluate factors affecting survival quality. Result The total mark of SF 36,marks of physical function,vitality,bodily pain and general health were respectively 61±29,23±31,52±21,32±35,50±28,48±25,45±21,51±17 and 59±18 in the treated group,while 83±25,82±36,76±19,84±30,82±20,62±23,73±26,76±25 and 76±9 in the control group. Statistically significant differences were found between the two groups( P <0.01).The factors affecting the marks of SF 36 of patients were focus on duration of disease,complications, elevated ALT,icterus and malaise. Conclusion The survival quality of patients with chronic hepatitis B declines. The main factors affecting the survival quality of the patients are focus on duration of disease,complications, elevated ALT,icterus and malaise.