经鼻面罩持续气道正压通气对支气管哮喘疗效的观察

Effect of nasal/face mask continuous positive airway pressure in bronchial asthma

目的 观察经鼻面罩持续气道正压通气 (nCPAP)对中度支气管哮喘的治疗效果。方法 6 2例中度哮喘急性发作者随机分为两组 ,观察组 32例 ,在药物治疗基础上铺以nCPAP ,对照组 30例 ,给予药物治疗 ,于入院治疗前 1h和治疗后 4h测定肺功能、血气分析 ,结合临床症状、肺部体征变化分析临床疗效。结果 观察组 :治疗后 ,FEV1.0 从 1.1± 0 .6L升至 1.3± 0 .6L ,动脉血pH从 7.2± 0 .2升至 7.3± 0 .1,PaO2 从 76 .0± 9.7mmHg升至 93.4±5 .7mmHg ,PaCO2 无明显变化。对照组 :治疗前后各参数无明显变化。胸闷及肺部哮鸣音在机械通气后好转 ,而对照组缓解不明显。P <0 .0 1,两组差异显著。结论 经鼻面罩持续气道正压通气对中度哮喘疗效确切。

Objective To assess the clinical effect of nasal/face mask continuous positive airway pressure in moderate asthmatic patients. Methods Sixty two patients with moderate asthmatic patients were randomly divided into observed and controlled groups.32 cases,in observed group were treated with deliver medication base and assisted by cCPAP,30 cases,in control group were administering medication.We examined the function of lung and vigour construe,1 hour before and 4 hour after the treatment,and assessed the clinic effect of these patients. Results Observed group:after treatment,FEV1.0 from 1.1±0.6L up to 1.3±0.6L,pH in artery blood from 7.2±0.2 up to 7.3±0.1,PaO 2 from 76.0±9.7mmHg up to 93.4±5.7mmHg,PaCO 2 had no obvious change. Control group above parameters had not obvious change before and after treatment.There were remarkably improvements between two groups( P <0.01). Conclusion Nasal/face mask CPAP in asthmatic patients is effective.