摘要
目的 评价国产卡马西平 (CBZ)在治疗躁狂发作中的临床实用性。方法 对 2 3例符合CCMD -2 -R中躁狂症诊断标准的患者进行CBZ治疗 4~ 6周的研究 ,其剂量为 0 .6~ 1.2 /d。分别以BRMS、CGI评定疗效和疗效指数 ,以TESS评定副反应、以TESS总评B项分评定痛苦程度和耐受性。结果 CBZ总有效率 64 % ,显效率 5 6% ;副反应发生率 84% (有 3例出现严重不良反应退出 ) ;平均疗效指数 (1.0 4± 0 .5 6) ;总评B项分接近 2分 (呈中度痛苦 ,勉强耐受 )。结论 CBZ治疗躁狂症不失为一种有效药物 ,但临床实用性不甚满意 ,不宜作首选药物。
Objective The purpose of this study was to evaluate clinical practicality of carbamazepine(CBZ) made in our country in treatment of manic episode.Methods 23 subjects met the CCMD-2-R criteria for manic episode were treated by CBZ with 0.6~1.2/day for 4~6 weeks.The efficacy and the efficacy indexes(EI) were assessed with BRMS and CGI.The side effects were assessed with TESS.The distress and the tolerance were assessed with B items of TESS.Results 16 subjects(64%) responded to CBZ with much improved (56%).The side effects rate(84%)were measured and 3 subjects suffered from severe side effects were discontinued.EI was 1.04±0.56.B items score of TESS approximated 2 where by there were moderate distress and strained tolerance.Conclusions The CBZ remained a effective drug,but its clinical practicality was'nt much satisfactory and would'nt select it firstly.
出处
《四川精神卫生》
2001年第1期33-35,共3页
Sichuan Mental Health