摘要
目的 探讨白细胞介素-12(IL-12)在带状疱疹(HZ)发病中的作用。方法 采用双抗体夹心ELISA法检测126例 HZ 患者血清中 IL-12水平,并对 33例 HZ 患者急性期和恢复期血清 IL-12水平进行了比较。结果 HZ 患者急性期血清中IL-12水平明显低于正常人(P<0.01)。33例患者恢复期血清IL-12水平较急性期明显升高(P<0.02)。结论HZ患者血清中IL-12水平与其病情活动性相关,IL-12可能参与了HZ的发病。
Objective To investigate the role of interleukin-12(IL-12) in the pathogenesis of herpes zoster(HZ). Methods Serum levels of IL-12 we determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 126 HZ patients and the serum IL-12 levels in acute and convalescent stage from 33 HZ patients were also observed. Results Serum IL- 12 levels were significantly lower in group of 126 HZ patients than those in the control group(P<0. 01). The serum levels of IL- 12 were significantly higher in convalescent stage than that in acute stage from 33 HZ patients (P<0. 02). Conclusion These results indicated that there is a relationship between the serum levels of IL-12 and the activity of HZ. The results the suggest that IL-12 may play an important role in the pathogenesis of HZ.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2001年第2期92-93,共2页
The Chinese Journal of Dermatovenereology