1999年广州地区所见淋球菌对抗生素耐药性结果分析

Analysis of Antibiotic Resistance of Neisseria gonorrhoeae in Guangzhou, 1999

目的了解广州地区所见淋球菌对抗生素的耐药性及产青霉素酶淋球菌（ＰＰＮＧ）和高水平耐四环素淋球菌（ＴＲＮＧ）的流行状况。方法用琼脂稀释法测定最低抑菌浓度（ＭＩＣ）以及用纸片碘量法检测β－内酰胺酶。结果１６７株淋球菌检出 ＰＰＮＧ ９株（５．４％）、ＴＲＮＧ １６株（９． ６％）、环丙沙星耐药率达 ７８． ４％，高度耐药株（ＭＩＣ≥１６ｍｇ／Ｌ）３７株（２２．２％），头孢三嗪、壮观霉素未发现耐药菌株，且抗菌活性最强，头孢三嗪敏感性是上升趋势。结论持续监测淋球菌的耐药性十分重要。

Objective To survey the antibiotic resistance and the prevalence of penicillinase-producing Neisseria gonor- rhoeae(PPNG) and high-level tetracycline resistant Neisseria gonorrhoeae(TRNG) in Guangzhou. Methods Minimum inhibitory concentrations(MIC) were determined using the agar dilution method and that of β-lactamase by paper iodin quantitative method. Results There were 9(5. 4% ) strains PPNG and 16(9. 6% ) strains TRNG in 167 strains Neisseriae gonorrhoeae. Resistant rates of ciprofloxacin was as much as 78. 4%. The high-level resistant stains(MIC≥16mg/L) were 37 (22. 2 % ). No resistance strain to ceftriaxone and specitinomycin, ceftriaxone susceptibility was improving. Conclusion The study showed that it is impor- tant to successively survey the antibiotic resistance of Neisseriae gonorrheae.