葡萄球菌性NGU的病原菌及耐药性检测

Detection of Pathogen and Drug Resistance of Staphylococcus Infection in Nongonococcal Urethritis

目的研究支原体、衣原体阴性的 ＮＧＵ患者葡萄球菌感染的特点及耐药性。方法采集 １０３例支原体、衣原体阴性的男性患者尿道分泌物，分离培养并以ＭｉｃｒｉＳｃａｎ微生物鉴定系统鉴定，同时检测各菌株最低抑菌浓度（ ＭＩＣ）。结果共分离出 ９种 ７２株葡萄球菌，分离车 ６９． ９０％，未发现混合感染：所有菌株均产生β－内酰胺酶。耐药率最高的５种抗生素为：青霉素１００％、红霉素９７．２２％、氨苄西林９５．８３％、四环素９３．０６％、苯唑西林８３．３３％，未发现耐万古霉素菌株。结论葡萄球菌是支原体、衣原体阴性的ＮＧＵ男性患者的重要病原体，尤其不能忽视凝固酶阴性葡萄球菌（ＣＮＳ）的致病性。治疗宜首选万古霉素。

Objective To study the infective characteristics and drug resistance of nongonococcal urethritis (NGU) of pa- tients with staphylococcus infection without mycoplasmas and chlamydia infection. Methods The male urogenital secreta from 103 cases with negative infection of mycoplasmas and chlamydia were collected and cultured. Staphylococcus were indentified and detected,minimal inhibiting concentration(MIC) was determined by MicroScan Microbiology system. Results There were 72 strains in 9 species of staphylococcus, isolate rate was 69. 90 %. No multinfection. All stratas were β-lactamase producable. Drug re- sistance rate: penicillin 100 %, erythromycin 97. 22 %, ampicillin 95. 83 %, tetracycline 93. 06 %, oxacillin 83. 33 %. No strain was found to be resistant to vancomycin. Conclusion The staphylococcus is the important pathogen in male patient without mycoplas- mas and chlamydia infection. CNS should be noticed..The first choice for the treatment of infection from staphylococcus is van- comycin.