洛赛克治疗症状性胃食管反流病95例临床观察

Clinical Observation of Treatment Effects to Symptomatic Gastroesophageal Refluence Disease(GERD) with Omeprazole(95 casea)

目的 :了解洛赛克强力抑酸作用对胃食管反流病 (GERD)患者临床症状改善及胃镜下食管炎症改善情况。方法 :将 95例GERD病人随机分为两组 ,用洛赛克 (2 0mgqd) 5 0例 ,雷尼替丁 (15 0mgBid) 45例 ,疗程 4周 ,停药 2周后胃镜复查 ,观察临床症状及食管炎症改善情况。结果 :治疗组临床症状改善有效率为 91.6% ,对照组为 5 0 .4%。治疗组胃镜下食管炎症改善有效率为 70 % ,对照组为 2 9.2 %。治疗组明显优于对照组。结论 :对GERD病人抑制胃酸分泌 ,减轻其对食管粘膜的损伤和改善临床症状洛赛克有较好的疗效 ,其作用已被公认 ,但在食管炎症愈合方面疗效不太满意 ,如与促动力药物合用 ,可望更高疗效。

Objective:To observe the treatment effectiveness to symptomatic gastroesophageal refluence disease(GERD) with omeprazole.Methods:95 patients with GERD were divided randomly into two groups,one which was treated by omeprazole(20mg qd)included 50 cases,the other treated by simitidine(150mg bid)included 45 cases.Two groups were treated for 4 weeks,then checked by endoscope,observed betterment of clinical symptom and esophageal phlogistic.Results:The efficacy of omeprazole group was 91.6%,however simitidine group was 50.4%;In endoscope the betterment of esophageal phlogistic was seen in 70% of the former,but only 29.2% of the latter.The omeprazole group was much better than the simitidine group.Conclusion:It has been well known that omeprazole can deaden gastric acid secreting which can damnify gastric membrane,and improve clinical symptom;However when to esophagealtitis,it works poor;Better effect might get by combining motivity medication.