老年高血压患者颈动脉内膜中层厚度及血管内皮依赖性舒张功能

Intima-Media Thickness of Carotid Arteries and Endothelium-Dependent Vasodilation Function in Elderly Hypertensive Patients

为评价老年高血压患者动脉粥样硬化的发病情况 ,利用高分辨率超声 ,对 6 3例老年高血压患者及 2 0例对照者颈动脉内膜中层厚度及斑块进行检测 ,并观察休息时、反应性充血后肱动脉内径变化。结果发现 ,高血压II期、III期颈动脉内膜中层厚度及斑块发生率较对照组明显增加 (P <0 .0 5 ) ,且随斑块严重程度的增加内膜中层厚度呈增厚趋势。高血压各期肱动脉血流介导性舒张较对照组明显减弱 (P <0 .0 5 )。结果提示 ,颈动脉内膜中层厚度增厚及血管内皮依赖性舒张功能障碍是老年高血压患者动脉粥样硬化的早期表现。

Aim To assess the extent of atherosclerosis in elderly hypertensive patients. Methods With high resolution ultrasound, not only intima-media thickness (IMT), plaque of carotid arteries, but also endothelium-dependent relaxing function were measured in 82 subjects, consisted of 62 patients with essential hypertension and 20 controls. Results IMTs of carotid arteries were higher in hypertensive patients than those in normal subjects (P<0.05). There was an increasing trend for IMT with the severity of plaque. Flow mediated dialtation in the groups with essential hypertension was much reduced compared with the control group (P<0.05). Conclusions Increases in IMT of carotid arteries and impairment of endothelium-dependent vasolidation are related to atherosclerosis in early stage in elderly hypertensive patients.