摘要
目的 :探讨胃恶性肿瘤病人氨基酸代谢变化与肿瘤进展程度之间的关系 ,为胃恶性肿瘤氨基酸失衡疗法提供理论依据。 方法 :采用 Beckm an- 6 30 0高效氨基酸自动分析仪 ,检测 41例胃恶性肿瘤组织和癌旁胃粘膜组织中 19种游离氨基酸的含量 ,对不同分期肿瘤组织氨基酸进行比较分析。 结果 :与癌旁胃粘膜组织比较 ,胃恶性肿瘤组织中牛磺酸、苏氨酸、丝氨酸、脯氨酸、甘氨酸、丙氨酸、缬氨酸、异亮氨酸、亮氨酸、酪氨酸、赖氨酸含量升高 (P<0 .0 5 )。进展期肿瘤与早期肿瘤相比 ,脯氨酸、缬氨酸、蛋氨酸、异亮氨酸、苯丙氨酸升高 (P<0 .0 5 )。 结论 :胃癌组织多种游离氨基酸含量显著高于癌旁胃粘膜组织 。
Objectives:To determine the content of aminoacids in gastric cancer tissue and study the relationship between alterations of amino acids and cancer stages. Methods:19 free amino acids of cancer tissue and paracancerous normal mucose were determined in 41 cases of gastric cancer. Results:Most free amino acids were significantly increased in gastric cancer tissue as compared with those of paracancerous normal gastric tissue.The contents of proline,valine,methionine,isoleucine,leucine in advanced gastric cancer were significantly higher than those in early cases. Conclusions:Gastric tumor tissue contains high amount of most free amino acids particularly in cases with advanced cancer..
出处
《肠外与肠内营养》
CAS
2001年第1期1-3,共3页
Parenteral & Enteral Nutrition
