丙氨酰谷氨酰胺二肽的代谢及在肠外营养中的应用

The metabolism of alanyl-glutamine dipeptide and its use in parenteral nutrition

谷氨酰胺 (Gln)具有许多重要的生理功能 ,但由于它的水溶解度低 ,在水溶液中不稳定 ,当加热灭菌时可生成有毒的焦谷氨酸和氨 ,使其应用受到限制。含 Gln的二肽丙氨酰谷氨酰胺克服了它的缺点 ,并可被机体快速有效地分解为丙氨酸和谷氨酰胺 ,被机体利用 ,而无任何毒副反应。

Although it has many important functions in physiology,glutamine is not used widely in clinic.Low dissolution and unstabitity in water are the main disadvantages of glutamine.L alanyl L glutamine dipeptide is the product of high dissolution and stability in water and can be metabolised and utilized rapidly in the body.The metabolism and clinical use of the dipeptide are reviewed here.