肌钙蛋白Ⅰ与不稳定型心绞痛预后的关系

The relation between cardiac troponin I and the prognosis of unstable angina

目的 :探讨肌钙蛋白 I( c Tn I)与不稳定型心绞痛 ( U A)患者预后关系。方法 :43例 U A患者于发病后 6h内采第1次血样 ,以后每隔 6h采 1次血样 ,至 2 4h后每天采血 1次 ,至 1周。同一份血样分别作肌酸激酶同工酶 ( CK -MB)、肌酸激酶 ( CK )、 c Tn I检测。结果 :43例 U A中 13例初发型劳累性心绞痛 c Tn I阳性者 0例 ,16例恶化型劳累性心绞痛中 c Tn I阳性者 1例 ,14例自发性心绞痛 c Tn I阳性者 5例。发生 AMI 5例 ( 4例为自发性心绞痛 ,1例为劳累性心绞痛 ) ;2例猝死患者为自发性心绞痛。结论 :自发性心绞痛患者 c Tn I阳性率明显高于初发型、恶化型心绞痛 ( P<0 .0 1) ,发生 AMI或猝死率与c Tn

Objective:It is to observe the relation between cardiac troponin I (cTnI) and the prognosis of unstable angina (UA). Methods: Blood samples of 43 UA cases were taken once every 6 hour in the first 24 hour and then once a day in a week. cTnI, CK MB and CK were measured for every blood sample. Results: All 13 UA cases of initial onset angina (IOA) were negative in cTnI. There was only one positive case in cTnI in 16 cases of progressive angina (PA). There were 5 positive cases in cTnI in 14 cases of onset angina by itself (OABI). Five cases developed AMI (four were OABI and one was PA). Two OABI patients developed sudden death. Conclusion: It is suggested that the positive rate of cTnI in OABI is significantly higher than that in IOA and PA (P<0.01). AMI and sudden death of UA patients were related to increase of cTnI