血液系统肿瘤中的人类错配修复系统

Human Mismatch Repair System in Hematologic Malignancies

人类错配修复 (mismatchrepair ,MMR)系统由MutH ,MutL和MutS三大家族的蛋白组成。它们修正核苷酸摄取错误、增强DNA复制忠实性、降低基因的自发突变率、维持着微卫星位点乃至整个基因组的稳定。MMR系统功能低下就有可能导致癌变发生 。

The human mismatch repair (hMMR) system consists of members of three super-families, namely MutH, MutL and MutS. They are able to correct the error of nucleotide incorporation, increase the fidelity of DNA replication, reduce spontaneous mutation, and maintain the stability of microsatellite loci and genome. The dysfunction of MMR may induce to carcinogenesis. The relation of MMR and hematologic malignancies is presented in the article.