淫羊藿总黄酮对摘除卵巢大鼠骨质疏松症的防治作用

Effects of Epimedium koreanum flavoids on osteoporosis in ovariectomized rats

用摘除卵巢法结合低钙饲料建立大鼠骨质疏松模型。淫羊藿总黄酮在 75～ 30 0mg kg剂量范围内连续给药 3个月 ,与模型组大鼠比较 ,能明显提高大鼠股骨表观面密度 (W LD)和骨密度(BMD)而不升高子宫系数及血清雌二醇 (s-E2 )水平 ,并有提高骨Ca、骨P的趋势。高剂量组大鼠血清碱性磷酸酶 (s -ALP)降低 ,股骨骨密度升高。骨形态计量学结果表明 ,高剂量组大鼠骨小梁吸收表面百分率 (TRS % )和形成表面百分率 (TFS % )等参数明显降低 ,骨小梁体积百分率 (TBV % )明显提高。

Ovariectomized rat models fed with low calcium diet were used to evaluate the effects of total flavoids of Epimedium koreanum Nakai (EKF) on osteoporosis.Three doses of EKF(75,150 and 300 mg/kg)were given orally for three months.Compared with control model group,EKF could increase femur W/LD( P <0 05) without raising the uterus index and serum estradiol level.300 mg/kg EKF decreased serum ALP in rats( P <0 05),and increased femur density( P <0 05).Bone histomorphometry showed that EKF decreased TRS% and TFS% at the dose of 300 mg/kg,but increased TBV%.\;