大前庭导水管综合征发生的危险因素

The risk factors to cause vestibular aqueduct syndrome

目的 :探讨影响前庭导水管发育的危险因素。方法 :对 36名大前庭导水管综合征 (LVAS)患儿进行病史调查和影像学检查。结果 :36例患儿中 7例有家族遗传史、1例放射遗传效应、宫内感染 2例、母孕期用药 2例、胎儿宫内发育迟缓 1例、母孕期心理障碍 2例、伴其它先天畸形 2例、原因不明 19例。CT显示有四种类型 :单纯前庭导水管扩大 (LVA) 14例、MondiniI型伴LVA 2例、MondiniⅡ型伴LVA 4例、MondiniⅢ型伴LVA 16例。结论 :遗传因素、孕期心理障碍、宫内感染、孕期用药、胎儿宫内发育迟缓均可导致LVAS的发生 ,应重视遗传因素的作用。

Objective:To explore the risk factors influenting vestibules aqueduct's development.Methods:To carry out clinical and imaging investigation on 36 children with the large vestibular aqueduct syndrome(LVAS).Results:there were familial hereditary tendency(n=7),radio\|hereditary effect(n=1),intro\|uterine infection(n=2),psychological obstacle in the pregnancy(n=2),taking medicine during pregnancy(n=2),with other congenital malformation(n=2),intro\|uterine growth retardation(IUGR)(n=1)and uncertain reason(n=19)in the 36.According to their CT findings,LVAS could be divided into following 4 types:enlargement of vestibule aqueduct(EVA)(n=14);Mondini I with EVA(n=2);Mondini Ⅱ with EVA(n=4);Mondini Ⅲ with EVA(n=16).Conclusion:The risk factors which resulted in LVAS were heredity,psychological obstacle in the pregnancy,intrea\|uterine infection,taking medicine during pregnancy and IUGR.So we should pay great attention to heredity factor's function and carry out a whole set of examination on these children.