单纯性肾病患儿甲状腺功能测定的临床意义

Determination of the Thyroid Function for Simple Nephropathy Children

目的 探讨单纯性肾病血清甲状腺素水平的变化。方法 用双抗体放免法检测肾病患儿组与健康对照组各 2 0例血清甲状腺素 ,比较两组变化的差异。结果 对照组血清甲状腺素水平正常 ,肾病组血清T3 ,T4 ,TSH有不同程度的变化 ,分别为 (1.0± 0 .5 )nmol/L ,(15 .5± 32 .4)nmol/L ,(2 0 .2± 13.2 )mU/L ,两组差异有显著性意义(P <0 .0 1)。结论 检测单纯性肾病患儿血清甲状腺素水平 ,对增进治疗效果 ,估计和改善预后有比较重要的意义。

Objective To investigate the changes of serum thyroid hormone levels in children with the simple nephrotic syndrome.Methods We measured the serum thyroid hormone levels in a group of simple nephrotic syndrome children (n=20) and a group of healthy controls (n=20) by radioimmunoassay double antibody (RIA-DA), and then compared the differences in serum thyroid hormone levels the 2 groups by a statistical method. Results The thyroid hormone levels in the contorl group were normal, but the serum T 3, T 4, TSH in the nephrotic syndrome group showed changes of different degrees. They were ( 1.0 ±0.5) nmol/L, ( 15.5 ± 32.4 ) nmol/L, and ( 20.2 ± 13.2 ) mU/L, respectively. There was a significant difference between the simple nephrotic syndrome group and the controls (P< 0.01 ). Conclusions There might be some significance in using serum thyroid hormone levels in children with the simple nephrotic syndrome for the improvement of management, curative effect and evaluation of prognosis.