幽门螺杆菌感染与胃癌关系——嵌入式的病例对照研究

Nested Case - Control Study on the Relationship of Hp Infection and Gastric Cancer Risk

目的 探讨幽门螺杆菌(Helicobacter pylori,Hp)感染与胃癌的关系。方法 1980～1988年参加山东省牟平县高陵镇和浙江岱山县胃癌普检的人群,胃镜活检组织蜡块切片Hp经Warthin Starry(WS)染色,判定幽门螺杆菌的感染状态。对这些人群随访,病例与对照按照年龄、性别和居住地匹配,实施1:4的嵌入式病例对照研究。结果 经过多因素条件Logistic回归调整和控制混杂因素后,显示Hp感染是胃癌的危险因素(OR=4.4467,95％CI 1.161-17.19),吸烟也与胃癌发生相关。结论 本研究以胃组织存在典型Hp作为Hp感染指标,证实Hp感染是胃癌的危险因素之一。

Objective The aim of tliis study was to explore the relationship of Helicobacter pylori (Hp) infection and gastric cancer risk.Methods Follow- up was conducted ainong those who had participated in 1980- 1988 gastric cancer census in Muping, Shandong Province and Daishan, Zhejiang Province.Hp infection was examined by Wartliin - Starring stain to the biopsy specimen stored. A nested case - control study was conducted, for each patient died of gastric cancer four controls was matched on residence, age and sex.ResultS After adjustment and control of confounding factors, the results of multiple variants conditional Logistic analysis showed tliat Hp infection (OR = 4.4467, 95% CI 1. 161 - 17.19) is a risk factor of gastric cancer.Smoking is also one of the risk factors of gastric cancer. Conclusions The result showed that Hp infection was one of risk factors of gastric cancer.