习惯性流产胚胎绒毛细胞LIF基因的表达

Expression of Leukemia Inhibitory Factor Gene of Chorionic Tissue from Habitual Abortions

本文采用RT-PCR技术对25例习惯性流产胚胎绒毛细胞和25例正常妊娠的人工流产绒毛细胞LIF基因表达进行了研究，以探讨胚胎绒毛组织LIF基因表达与流产之病因的关系。结果发现在流产组中，有5例（占20%）流产胚胎绒毛组织无LIF基因表达，而正常组绒毛组织中均检测到LIF基因表达，两组经统计学处理具有显著性差异（P＜0.01）。本研究结果提示胚胎绒毛组织LIF基因表达缺陷可能是造成流产的原因之一。

In order to find out relationship between expression of leukemia inhibitory factor(LIF) of chorionic tissue and habitual abortio n, expression of LIF of chorionic tissues from 25 cases habitual abortions a nd normal controls was analysized by reverse transcription-polymerase chain reac tion method. The result showed there was no expression of LIF in 5 chorion t issue samplings from habitual abortion(20%). There is a significant difference b tween the two groups(P＜0.01).The findings suggest that cause of habitual ab ortion might be related to no-expression of LIF gene.