头孢菌素类药物致过敏性休克148例分析

Analysis of 148 cases with allergic shock induced by cephalosporins

目的:调查了解头孢菌素类药物的不良反应情况。方法:本文就我们遇到的病例及1986年～2000年6月国内文献报道148例头孢菌素类药物所致严重过敏性休克病例进行综合分析。结果:头孢菌素类药物过敏反应来势凶险,死亡率高,提请临床应用时提高警惕,并就抢救及皮试等问题进行探讨。

Objective: To investigate the adverse reactions of cephalosporins. Methods: 148 cases with allergic shock were collected and analysed mostly through Chinese literature retrieval of 1986 - 2000 in addition to a few patients of our hospital. Results: The shock appeared immediately after the drug administration in 66 cases with a severe nature and death followed if the first aid delayed. Conclusion: The treatment of shock and the skin test of drug were discussed. More attention should be attached to the shock associated with cephalosporins.