摘要
观察了急慢性应激时大鼠胃组织钙及cAMP含量的变化,以及异搏定抗应激性溃疡作用与胃组织钙及cAMP 含量变化之间的关系。结果表明:(1)应激后,在形成胃粘膜损害的同时,伴有胃粘膜钙含量明显增高,胃组织cAMP 含量则减少;(2)事先给予异搏定,胃组织cAMP 含量显著升高,同时胃粘膜损害明显减轻。提示应激时胃组织钙及cAMP 含量的变化在胃粘膜损害的形成中可能有一定的作用。
The changes of gastric tissue contents of calcium and cAMP inacute and chronic stressed rats and in rats pretreated with verapamil wereinvesigated.The results showed:(1)a significant increase in gastricmucosal calcium con(?)ent and a remarkable decrease in cAMP were observed afterstress.In the mean(?)ime,serious gastric mucosal lesions occurred;(2)Pre-treatment with verapamil could (?)aise the gastric cAMP content andalleviate the mucosal lesion.It is suggestive that changes of gastric calciumand cAMP contents may have some bearing on the formation of stress gastriculcer.
关键词
应激
钙
维拉帕米
胃粘膜损害
stress
calcium
cAMP
verapamil
gastric mucosal lesion
rats
