甲胎蛋白岩藻糖指数对肝癌复发的预测作用

The implication of fucosylation index of serum alpha-fetoprotein in predicting recurrence of hepatocellualr carcinoma

肝癌是术后复发率较高的癌肿之一。为了探讨血清ＡＦＰ岩藻糖指数对肝癌复发的预测作用，本文以１８例术后ＡＦＰ未能转阴的肝癌患者的对象，研究手术前后血清ＡＦＰ岩藻糖指数的变化类型，并结合随访结果进行队发析。结果表明，２例术前ＡＦＰ及岩藻糖指数均较低，术后两值无明显变化，１年后未见复发；５例术前两值较高，术后两值明显降低，１年后亦无１例复发；１１例术后ＡＦＰ明显降低，甚至达很低水平，但岩藻指数为化不大，其中７例在半年内复发，１例在９个月复发。提示ＡＦＰ岩藻糖指数是肝癌的特异性敏感指数。观察肝癌术后ＡＦＰ岩藻糖指数变化，有助于我们判断肝癌是否得到根治切除或余肝是否存在肝硬变活动，从而准确地评估疗效，预测复发。

Hepatocellualr carcinoma(HCC)is among the most easily recurrent cancers.In order to explore the usefulness of fucosylation index of serum alpha-fetoprotsin (AFP)in predicting tumor recurrence, the relationship between the postoperative change patterns of fucosylation index of AFF and the follow-up results was studied in 18 patients with HCC,in whom serum AFP didn't turn negetive after tumor resection,In 2 patients,both AFP and fucosylation index were lower preoperatively, and remained unchanged postoperativey;In 5 patients,both two values were higher preoperatively,and obviously decreased postoperatively,No evidence of tumor recurrence was found in all the above-mention patients within 1 year,In 11 patients,serum AFP levels markedly dropped postoperatively,even to a very low level,but fucosylation index showed farely constant. of them,tumor relapsed in 7 patients within 6 months,andrelapsed in 1 patient at 9 month,These results indicate that fucosylation index of AFP may be a sensitiVe index of tumor activity, the obvervation of poatoperative changes of fucosylation index should aid in evaluating treatment effect and predicting tumor recurrence.