P^(16)基因蛋白在子宫颈鳞癌组织中的表达

P 16 Expression in Cervical Squamous Cell Carcinoma

应用免疫组织化学方法对５８例子宫颈鳞状上皮细胞癌及５例宫颈上皮内瘤样病变标本的Ｐ１６基因表达进行研究，取８例正常子宫颈组织作对照。结果显示：Ｐ１６基因免疫反应产物主要定位于细胞浆内，阳性细胞在组织中的分布呈巢状、灶性或分散性。Ｐ１６基因的阳性表达率在宫颈鳞癌、宫颈上皮内瘤样病变及正常宫颈组织中分别为４３１％、４０％和１２５％。肿瘤病理分级越低，临床分期越晚，阳性表达率越低，差异有显著性（Ｐ＜００５）。提示：Ｐ１６基因的异常表达在子宫颈鳞癌的发生。

The P 16 expression of seventy-one paraffin-embedded specimens from 58 cervical squamous cell carcinoma,5 cervical intraepithelial neoplasis (CIN) and 8 normal cervices were studied by using immunohistochemical method.The results showed that the cytoplasmic P 16 protein expression was mainly found.Positive cells were demonstrated in nesty,focal or scattered distribution.The positive rate in carcinoma,intraepithelial neoplasma and normal cervix were 43.1%、40% and 12.5% respectively.Positive expression were decreased in lower grade and advanced cases ( P <0 05).It suggests that the abnormal P 16 expression might play an important role in the tumorigenesis and tumor development of the cervical squamous carcinoma.