急性脑梗塞抗氧化治疗的疗效观察

Theefectofantioxygenonacutecerebralinfarction

为了研究自由基清除剂甘露醇及抗坏血酸（ＶｉｔＣ）在急性脑梗塞中的作用，将急性脑梗塞患者１０３例分３组，分别给予小剂量甘露醇或大剂量ＶｉｔＣ和血塞通治疗，对照组只给予血塞通静脉滴注，疗程为１４天。结果显示，小剂量甘露醇及大剂量ＶｉｔＣ组在治疗后与对照组比较，神经功能损伤明显减轻。小剂量甘露醇组治疗后ＣＴ检查显示，梗塞灶明显减小，而大剂量ＶｉｔＣ组及对照组则无明显改变。结果提示，脑梗塞早期应用具有抗氧化作用的药物，如小剂量甘露醇及大剂量ＶｉｔＣ对急性脑梗塞有治疗作用。

Inordertostudythefreeradicalscavengers,mannitol(M)andascorbicacid(VitC)forprotectingagainstischemicbraininjury,theauthorsmadeastudyof103patientswithacutecere-bralinfarctiontreatedwithlow-doseMorhigh-doseVitCandXue-Sai-Tong,andagroupofcontrolpatientsonlyreceivedXue-Sai-Tongfor14days.Theresultsindicatedthatthelow-doseMgroupandthehigh-doseVitCcouldreducetheneurologicaldamagesignificantlycomparedwiththepatientsofthecontrolgroup.BrainCTscansshowedthattheinfarctionvolumeswerereducedsignificantlyinthepatientsofthelow-doseMgroupandfailedtoshowanydiferenceinthehigh-doseVitCgroupandthecontrolgroup.Theseresultssuggestthatthelow-doseMandthehigh-doseVitCmightprovetobesuibleasanadjuvanttherapyforthepatientswithacutecerebralinfarction.