摘要
为了探讨烟雾病的病因和发病机理，用静脉注射马血清、颈局部注射马血清、颈动脉部分结扎和颈局部注射去甲肾上腺素等４种方法，建立４组烟雾病实验动物模型。结果：静脉和颈局部注射马血清两组动物的颈动脉受免疫复合物损伤后，内弹力层迂曲、断裂，中膜平滑肌细胞沿断裂处向内膜伸入增生，以致管腔狭窄或闭塞，最终因长期慢性缺血，脑内小血管及毛细血管代偿性增生，形成烟雾样血管网，与人类烟雾病在影像学、病理学和免疫组织化学等方面结果相似。揭示了变态反应，尤其是颈局部发生的免疫损伤是引起原发性烟雾病的直接病因。
FourexperimentalanimalsmodelsofMoyamoyadiseasewereestablishedbytheau-thorswithnormalhorseserumbeinginjectedintotheveinsortheneckregionsaroundbothsidesofthecommoncarotidarteries,asbothcommoncarotidarterieswerenarowedwithsilkligatureorwithnoradrenalininjectedlocalyintotheneckareasaroundbothsidesofthecommoncarotidarter-ies.Afterthecarotidarterieswereinjuredwiththeimmunologicalcomplecesinthetwogroupsoftheveinsandtheneckpartsaroundbothsidesofthecommoncarotidarteriesinjectedwithhorseserum,theelasticfibrouslaminasofthecarotidarteriesbecametortuousandcracked,thesmoothmusclescelsimmigratedtowardthelumenalongtheregionsofelasticfibrouslaminascracks,leadingtocarotidarteralstenosisorocculusion.Eventualy,smalarteriesandcapilariesgrewwithcompensa-tionandformedMoyamoyadiseaseafteralongtimeofchronicischemia.Thefindingsofthepatholo-gy,imagingandimmunohistochemistrybetweenthehumanMoyamoyadiseaseandexperimentalani-malsseemedtobesimilar.Theexperimentalresultindicatedthattheimmunologicalresponse,espe-cialytheimmunologicaldamageattheneckareas,mightbeconsideredtobeadirectpathogeneticfactorofMoyamoyadisease.
出处
《中华神经科杂志》
CAS
CSCD
1996年第3期178-181,共4页
Chinese Journal of Neurology
基金
吉林省科委研究基金
关键词
烟雾病
病因
病理
ImmunediseaseCarotidarterySmoothmuscleMoyamoyadisease
