摘要
为了观察癫痫全身强直－阵挛性发作患者长时间服药后症状和ＥＥＧ的变化规律，探讨ＥＥＧ与临床药效之间的关系，采用国内推荐的ＥＥＧ及疗效评定标准，以定期随访的手段，对每个患者连续随访２年以上。结果：随服药时间延长，临床疗效无显著降低（服药半年与２年疗效比较，Ｐ＞０．０５）；而治疗前后ＥＥＧ异常率则有显著差异（Ｐ＜０．００１）；不同疗效患者治疗前的ＥＥＧ异常率无显著差异（Ｐ＞０．０５），接受药物减量治疗２年的完全控制者中有１９％的复发率，复发与未复发两者在药物减量前ＥＥＧ异常率无显著差异（Ｐ＞０．０５）。结果显示，临床症状好转，则ＥＥＧ异常率也相应减低，但非线性关系，临床药效与ＥＥＧ异常率的高低无明显对应关系，实施药物减量治疗，患者的复发率与药物减量前ＥＥＧ异常率及异常程度无明显关联。
TheauthorsobservedthesymptomandEEGchangeinthepatientssuferingfromgeneraltonic-clonicepilepticseizuresanddiscussedtherelationshipbetweenEEGandclinicalefectsaftertakinganti-epilepticforalongperiod.Aregularfolow-upstudywasmadeineverypatientinthewholeseriesforovertwoyears.EEGandthecriteriaforevaluatingtheeficacyoftheantilepticswereused.Theresultsshowedthatastheperiodoftakingtheanti-epilepticswasprolongedfromhalfayearto2years,theclinicalcurativeefectswerenotsignificantlyreduced,buttherewasanobviousdiferentrateofabnormalEEGbetweenthepre-treatmentandthepost-treatmentpatients(P<0.001)。Therelapseratewas19%inthepatientswhosesymptomshadbeencontroledfortwoyearswithreducingdosageoftheanti-epileptic.TherewerenoobviousdiferencesintheabnormalEEGrateandinthepatientswhohadarelapseandnorelapsbeforeusingthereducingdosage(P>0.05).Theauthordrewtheconclusionthatasthesymptomsimproved,theabnormalEEGratewasreduced,buttherewasnolinercorelationbetweenthesymptomsandtheEEGrate.TherewasonobviouscorelationbetweentheabnormalEEGrateandtheclinicalcurativeefects.Therelapserateindosage-reducingpatientsusingthereducingdosagewasneitherrelatedtotheabnormalEEGratenortotheseverityofEEGabnormalitiesbeforereducingdosagewasused.
出处
《中华神经科杂志》
CAS
CSCD
1996年第3期182-185,共4页
Chinese Journal of Neurology
