大鼠主动脉内皮剥脱后平滑肌细胞增殖与c－myc基因表达的研究

c-myc Expression and Vascular Smooth Muscle Cell Proliferation After Rat Aortic Injury

用Ｆｏｇａｒｔｙ导管对２５只大鼠行主动脉内皮细胞剥脱。在剥脱后的２４ｈ、５天、１０天、１５天时观察，发现主动脉平滑肌细胞增殖和内膜增厚随时间延长而降低，２０天接近基础水平。结果表明，ｃ－ｍｙｃ基因表达可能在启动平滑肌细胞增殖和内膜增厚中起重要作用。

To understand the molecular events governing smooth muscle cell(SMC) prolifetation in vivo, SMC proliferation and c-myc expression were assessed in aorta in 25 male rats. Balloon-injury to rat aorta evoked platelet adhesion after 24 h and induced increases of SMC proliferation and intimal thickening after 5, 10 and 15 days. c-myc expression increased significantly 24 h, but decreased gradually 5, 10, 15 and 20 days after the injuryThe results indicate that c-myc gene expression corroborates the platelet adhesion and autocrine mode of smooth muscle cells.