摘要
<正> 自60年前发现青霉素以来,已报道的抗生素有5000多种,其中60%以上由放线菌产生,并且大部分来自链霉菌。现已证明链霉菌的基因组大小约为10~4 kb,是大肠杆菌的2倍多,染色体为环形,许多菌中有从4kb 到20kb 大小不同。
出处
《国外医药(抗生素分册)》
CAS
北大核心
1991年第4期241-247,共7页
World Notes on Antibiotics
参考文献1
-
1王以光.抗生素产生菌链霉菌基因表达与调节[J]中国抗生素杂志,1988(05).
同被引文献21
-
1Goodfellow M, Williams S T, Mordarski, et al. Actinomycetes in Biotechnology[M]. New York: Academic Press,1988.
-
2Chakraborty D, Mondal B, Pal S C, et al. Characterization and identification of broad spectrum antibiotic producing StreptomyceshygroscopicusD1.5[J]. Hind Antibiot Bu11,1995,37:37-43.
-
3Chater K F. Multilevel regulation of Streptomycetes differentiation [J]. Trends Genet,1989,5:372-373.
-
4Tamura N, Pfeifer G, Baumeister W, et al. Tricom protease in bacteria: Characterization of the enzyme from Streptomycescoelicolot[J]. Biol Chem,2001,382:449-458.
-
5Marija A, Ivana L, Tamara K, et al. Purification and properties of extracellular lipase from Streptomyces rimosus, Enzyme[J]. Microbiol Technol, 1999,25:522-529.
-
6McDonald L A, Lotvin J A, et al. An Biosynthesis of ganefromycin: Results from blocked mutants and bioconversion experiments[J]. J Nat Prod, 1998,61:217-226.
-
7Bhattacharyya B K. Antibiotic resistance-A close look[J]. Hind Antibiot Bull, 1999,41:25-31.
-
8Bentley S D, Chater K F, Challis G L, et al. Complete genome sequence of the model actinomycete Streptomycvs coelicolor A3(2)[J]. Nature (lond),2002,417:1141.
-
9Bibb M J, Schottel J L, Cohen S N. A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces[J]. JBacteriol, 1982,151:668-677.
-
10Malpartida F, Hopwood D A. Molecular cloning of the whole biosynthetic pathway of a Streptomycetes antibiotic and its expression in heterologous host[J]. Nature,1984,309:462-464.
-
1马云鹏.链霉菌抗生素生物合成基因的克隆策略[J].国外医药(抗生素分册),1990,11(4):246-248.
-
2KeithF.Chater,崔丽薇.采用基因工程技术提高链霉菌抗生素产量的进一步设想[J].国外医药(抗生素分册),1991,12(3):167-171.
-
3黄凌燕.链霉菌抗生素生物合成基因表达与调节[J].国外医药(抗生素分册),1994,15(3):161-164. 被引量:2
-
4D.A.Hopwood,姜成林.链霉菌抗生素生物合成和孢子形成的遗传控制[J].国外医药(抗生素分册),1990,11(2):81-84.