尿钠、钾与血压的关系和钾的降压作用

URINARY SODIUM, POTASSIUM AND BLOOD PRESSURE AND HYPOTENSIVE EFFECT OF POTASSIUM ON HYPERTENSION

根据有或无高血压家族史,将90名正常血压者分为两组,连续三天测血压及定量分析8h夜尿钠、钾、肌酐。9例高血压病患者口服氯化钾2周,观察尿电解质及血压的改变。结果显示,收缩压和舒张压均与尿钾/肌酐值呈单因素负相关;多元回归分析则示有家族史者的尿钠与与舒张压正相关。高血压病人补钾后,血压明显降低,从而进一步说明钠、钾与血压有关。可考虑用低钠高钾膳食作为高血压病的综合防治措施之一。

Ninety normotensive sub jects( group A) were divided into two groups, the group with family history of hypertension(group B)and the group without family history of hypertension( group C).Nine patients with hypertension were given oral administration of potassium chloride for two weeks. All of them received measurement of blood pressure and determination of consecutive three days timed-night urinary cations; and the data collected were treated by simple factor correlation and multiple regression analysis. The results were as follows: 1. a negative correlation between blood pressure( both systolic and diastolic) and urinary K/Creatinine ratio, 2. a positive correlation between urinary Na and diastolic pressure in group B, 3. Systolic pressure, urinary Na/K ratio and Na/Creatinine of group B were higher than that of group C 4. a lowered blood pressure(3. 33kPa in systolic and 1.33 kPa in diastolic respectively) in hypertensi ves after oral administration of potassium chloride. This suggests that a low sodium and high potassium diet may be helpful in prevention and treatment of hypertension.