慢性乙型肝炎重叠戊型肝炎病毒感染与肝炎重症化关系的临床观察

The relationship of HBV-HEV superinfection and hepatitis aggravation

目的 为探讨慢性乙型肝炎重叠戊肝病毒 (HEV)感染与肝炎重症化的关系。 方法 对771例慢性乙肝患者进行酶联免疫吸附试验 (ELISA) ,放射免疫试验 (RIA)和斑点杂交试验检测甲、乙、丙、丁、戊型肝炎病毒感染和肝功能检测。结果 经临床观察、对照和分析 ,发现重叠HEV感染的慢性乙肝患者的重型肝炎发生率和慢性乙肝重度发生率高。 结论 提示HBV/HEV重叠感染在肝炎重症化过程中起着重要的作用。

Objective To explore the relationship of HBV-HEV superinfection and hepatitis aggravation. Methods HAV, HBV, HCV, HDV and HEV antigens or antibodies of 771 chronic hepatitis B patients were detected by ELISA, RIA and dot blot hybridization. Their liver functions were also examined. Results When chronic hepatitis B patients were superinfected by HEV, the incidence rate of hepatitis gravis and severe hepatitis was higher. Conclusion HEV superinfection played an important role in the progression of hepatitis B.