黄芪注射液治疗银屑病患者的临床观察和实验研究

Clinical and Experimental Observation on Treatment of Psoriasis with Radix Astra gali Injectio

目的观察黄芪注射液治疗银屑病的临床疗效并对其可能的作用进行实验研究。方法 各 31例寻常型银屑病分别用综合治疗和在此基础上加用黄芪注射液 ,对比观察临床疗效。 同时研究黄芪煎剂和黄芪注射液对小鼠阴道上皮细胞增殖、增殖细胞核抗原表达、鼠尾鳞片 表皮分化和血浆内皮素－1水平的影响。结果加用黄芪注射液与单纯综合治疗相比皮疹消退 时间明显提前，治愈率明显提高。动物实验表明黄芪注射液对上述 4个指标均有作用。其作 用均比黄芪煎剂强。结论黄芪注射液治疗银屑病有效，其作用可能是阻断多个发病环节。

Objective T o observe the therapeutic effect of Radix Astragali Injectio on psoriasis and it s possible pharmaceutical mechanism. Methods Two groups of patients with psoriasis vulgaris were treated with either comprehensive regi men or comprehensive regimen plus Radix Astragali Injectio. The clinical respons es in both groups were compared. Meanwhile, the effects of Radix Astragali Decoc tion and Injectio on proliferation of vaginal epithelium, PCNA expression, diffe rentiation of tail scale epidermis and plasma ET－1 were assessed in mouse mode l. Results It was shown that psoriatic lesions began to fade significantly earli er in Radix Astragali group than in routine comprehensive treatment group. The c linical cure rate was significantly higher in Radix Astragali group also. Animal experiment indicated that Radix Astragali Injectio had effects on all 4 indices mentioned above and the effects of the Injectio was stronger than that of the D ecoction. Conclusions Radix Astragali Injectio is effective for psoriasis vulgar is. Its therapeutic effects may be explained by blocking multiple pathogenetic l inkage.