大鼠侧脑室脑室下层的免疫组织化学研究

Immunohistochemical Studying on Subventricular Zone in Lateral Wall of Lateral Ventricle of Adult Rat

目的 探讨正常成年大鼠侧脑室脑室下层细胞定位关系。方法 用免疫组织化学 ABC法。结果 侧脑室前部外侧壁的脑室下层细胞表现为多唾液酸神经细胞粘附分子和磷酸酪氨酸阳性 ,并且二者在脑室下层的分布是一致的 ;而小白蛋白则在脑室下层表现为阴性。结论 脑室下层存在可增殖的神经元前体细胞 。

Objective The cells of subventricular zone in lateral wall of lateral ventricle of adult rats were localized. Method Immunohistochemistry. Results Polysialylated neuronal cell adhesion molecule and phosphotyrosine immunoreactive cells were found in subventricular zone, and they have same distributions, however, no any parvalbulin immunoreactive cells were found in subventricular zone. Conclusion neuronal precursor cells in subventricular and expression of phosphotyrosine are associated with proliferation of neuronal precursor cells in subventricular zone.