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Ⅳ型胶原酶的基因结构及表达调控 被引量：2

Type Ⅳ collagenase gene structure and regulation of gene expression
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摘要 Ⅳ型胶原酶是与肿瘤的侵袭和转移密切相关的一种蛋白水解酶。本文首先叙述了两种类型 型胶原酶的基因结构、功能区域及二者的区别 ,然后以 92 k Da 型胶原酶为重点从 ras的作用、 JNK与 ERK依赖性信号传导途径及 Ca2 +
作者 张亚辉 王芸庆 宋今丹
机构地区 中国医科大学卫生部细胞生物学重点实验室
出处 《解剖科学进展》 CAS 2001年第1期75-77,共3页 Progress of Anatomical Sciences
关键词 Ⅳ型胶原酶 基因结构 基因表达 基因调控
分类号 Q556.9 [生物学—生物化学] Q754 [生物学—分子生物学]
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参考文献13

  • 1[1]Huhtala P, Eddy RL, Fan YS, et al. Completion of the primary structure of the human type Ⅳ collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16. Genomics, 1990,6:554
  • 2[2]Huhtala P, Chow LT, Tryggvason K. Structure of the human rype Ⅳ collagenase gene. J Biol Chem, 1990,265(19):11077
  • 3[3]Whitham SE, Murphy G, Angel P, et al. Comparison of human stromelysin and clooagenase by cloning and sequence analysis. Biochem J, 1986,240:913
  • 4[4]Huhtala P, Tuuttila A, Chow LT, et al. Complete structure of the human gene for 92 kDa type Ⅳ collagenases. J Biol Chem, 1991,266(25):16485
  • 5[5]Wilhelm SM, Collier IE, Marmer BL, et al. SV40-transformed human lung fibroblasts secrete A 92 kDa type Ⅳ collagenases which is identical to that secreted by normal human macrophage. J Biol Chem, 1989,264(29):17213
  • 6[6]Quinones S, Sauc J, Otani Y, et al. Transcription regulation of human stromelysin. J Biol, Chem, 1989,264:8339
  • 7[7]Fini ME, Plucinska IM, Mayer AS, et al. A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. Biolchemistry, 1987,26:6156
  • 8[8]Murphy G, Ward R, Hembry RM, et al. Chracterization of gelatinase from pig polymorphonuclear leucocytes. Biochem J, 1989,258:463
  • 9[9]Stetler-Stevenson WG, Liotta LA， Kleiner DE. Extracellular matrix 6: role of matrix metalloproteinases in tumo invasion and metastasis. FASEB J, 1993,7:1434
  • 10[10] Gum R, Lengyel E, Juarez J, et al. Stimulation of 92 KD gelatinase b promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem, 1996,271(18):10672

同被引文献22

  • 1方伟岗.肿瘤细胞侵袭转移的分子生物学基础[J].中华医学杂志,1994,74(7):447-450. 被引量：10
  • 2江现强,刘志明,赫军,陆云飞.MMP-2在甲状腺癌中的表达及其临床意义[J].广西医科大学学报,2005,22(6):868-870. 被引量：3
  • 3刘联,张昕,王秀问,黎莉,于学军,徐从高.E-钙粘素介导的细胞粘附通过EGFR激活卵巢癌细胞PI3K-Akt信号通路[J].现代妇产科进展,2007,16(4):270-273. 被引量：9
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  • 5Kristina Dalberg,Elina Eriksson,Ulla Enberg,Magnus Kjellman,Martin B?ckdahl.Gelatinase A, Membrane Type 1 Matrix Metalloproteinase, and Extracellular Matrix Metalloproteinase Inducer mRNA Expression: Correlation with Invasive Growth of Breast Cancer[J].World Journal of Surgery.2000(3)
  • 6Heike Allgayer,Rudolf Babic,Klaus Uwe Grützner,Bianca C. M. Beyer,Anwar Tarabichi,Friedrich Wilhelm Schildberg,Markus Maria Heiss.Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns[J].Clinical and Experimental Metastasis.1998(1)
  • 7Eliyahu D,Raz A,Gruss P,et al.Participation of p53 cellular tumour antigen in transformation of normal embryonic cells[].Nature.1984
  • 8Finaly CA,Hinds PW,Levine AJ.The p53 proto-oncogene can act as a suppressor of transformation[].Cell.1989
  • 9Schutz A,Schneidenbach D,Aust G,et al.Differential expression and activity status of MMP-1, MMP-2 and MMP-9 in tumor and stromal cells of squamous cell carcinomas of the lung[].Tumour Biology.2002
  • 10Sier CF,Kubben FJ,Ganesh S,et al.Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma[].British Journal of Cancer.1996

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解剖科学进展
2001年 第1期

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