小升麻中的环菠萝蜜烷型三萜及其糖苷成分

CYCLOARTANE TRITERPENES AND GLYCOSIDES FROM CIMICIFUGA ACERINA

目的 研究小升麻 [Cimicifugaacerina (Sieb .etZucc.)Tanaka .]根茎的化学成分。 方法 小升麻根茎的乙醇提取物经硅胶柱和ODS柱色谱分离得到 5个化合物 ,通过波谱和化学方法进行结构鉴定。结果 5个化合物分别被鉴定为 ( 2 2R) 2 2 羟基升麻醇 (I) ,( 2 2R) 2 2 hydroxy 2 4 O acetylhydroshengmanol 3 O β D xylopyranoside(II) ,dahurinol (III) ,2 4 epi 2 4 O acetyl 7,8 didehydroshengmanol 3 O β D xylopyranoside (IV)和 2 5 O 乙酰基 7,8 去氢升麻醇 3 O β D 吡喃木糖苷 (V)。 结论 I为新天然产物 ,II为新化合物 。

AIM To investigate the chemical constituents from the rhizomes of Cimicifuga acerina (Sieb. et Zucc.) Tanaka. METHODS Column chromatgraphy (including silica gel and ODS) together with HPLC was used to separate the chemical constituents whose structures were determined by FAB-MS, NMR (1D and 2D) and hydrolysis methods. RESULTS Five cycloartane triterpenoids were isolated and identified as: (22R)-22-hydroxycimigenol (I), (22R)-22-hydroxy-24- O -acetylhydroshengmanol 3- O -β- D -xylopyranoside (II), dahurinol (III), 24- epi -24- O -acetyl-7,8-didehydroshengmanol 3- O -β- D -xylopyranoside (IV), 25- O -acetyl-7,8-didehydrocimigenol 3- O -β- D -xylopyranoside (V). CONCLUSION Compound I is a new natural product, compound II is a new compound and compounds IV and V were isolated from this plant for the first time.