10种雄性大鼠的中医体质学初步研究

Preliminary Study on TCM Crasiology in 10 Strains of Male Rats

为了对10种北京市目前常用的雄性实验大鼠进行中医体质检测,用雄性大鼠,品系有WistarⅠ级、Ⅱ级、Ⅲ级,SDⅠ级、Ⅱ级、Ⅲ级,CD(SD)IGSⅢ级(大、小体重),SHRⅠ级,SHR/spⅠ级。观测外观、大便、舌象、体温、肾上腺、胸腺、脾脏湿重,测定下丘脑—垂体—甲状腺轴相关功能。结果,WistarⅠ级、Ⅱ级、Ⅲ级,SDⅢ级大鼠体质基本正常,SDⅠ级大鼠略有虚热体质,SD Ⅱ级大鼠有实热体质,CD(SD)IGS Ⅲ级(小、大)大鼠略有虚性体质,SHRⅠ级大鼠略有虚寒体质,SHR/spⅠ级大鼠有明显虚寒体质,表明不同品系、同品系不同微生物等级、纯系与非纯系、不同年龄大鼠的中医体质比较有一定差异。

Ten strains of male rats are commonly used for experimental study at present in Beijing. The rats' outward appearence, stool, picture of the tongue, body temperature, and wet weight of adrenal gland, thymus gland and spleen were observed, and the function of the hypothulamus pituitary thyroid axis was determined. Results showed that the constitution of Wistar grade Ⅰ, Ⅱ, Ⅲ, and SD grade Ⅲ were basically normal. SD grade Ⅰ had the constitution of mild deficiency - cold, SD grade Ⅱhad constitution of excess - heat, CD (SD) IGS grade Ⅲ (small or big body weight) had constitution of mild deficiency, SHR grade I had constitution of mild deficiency -cold, SHR/sp grade I had obvious deficiency -cold constitution; There was a certain difference in TCM constitution among different strains, same strain with differrenct microbic grades, pure line and inbred line, and different ages in rats. It is indicated that the study on TCM crasiology in experimental animals are not only necessity, and also feasibility.