消化性溃疡与螺杆菌关系的临床病理研究

Pathological Study of 110 Patients with Peptic Ulcer

目的 :探讨消化性溃疡 (PU)与胃内螺杆菌感染的关系。方法 :以Warthin_Starry银染色和石碳酸_碱性品红染色 ,高倍镜和油镜下观察螺杆菌感染状况 ,然后与临床对比分析。结果 :①十二指肠溃疡 (DU) 89例 ,胃溃疡 (GU) 14例 ,胃十二指肠复合溃疡 (GDU) 7例。 79例幽门螺杆菌 (Hp)阳性 ;16例海尔曼螺杆菌 (Hh)阳性 ;Hp与Hh混合感染 13例 (DU占 10例 ) ;②PU病变重 :溃疡较大 ,双溃疡 ,多溃疡和GDU比例大 ,并发穿孔出血比率高 ;③PU伴随之慢性胃炎病变重 ,其重度炎症占 77 2 7%。慢性萎缩性胃炎 (CAG)及肠上皮化生相对较少。结论 :PU与Hp、Hh的感染或混合感染有直接或间接的关系 ,值得深入探讨。

Objective:To investigate the relationship between the peptic ulcer(PU)and spiral organism(spirillum)infection.Methods:The specimens from 110 cases of PU confirmed by gastroscopic and pathologic examinations(gastroscopy biopsy 77,gastroresection 33)were stained by Warthin_Starry silver stain and Carbolic acid_Basic fuchsin stain.The spiral organism was observed microscopically using high power lense and oil lense.Results:Among the 110 cases,there were Helicobacter pylori positive in 79 cases, Helicobacter heilmannii positive in 16 cases,mixed infection of H pylori and H heilmannii in 13 cases (in which,10 cases of DU).PU(77 27%) associated with severe chronic gastritis,but the chronic atrophic gastritis(CAG)and intestinal epithelial metaplasia were not often found.Conclusion:The high incidence of PU associated with the infection of H pylori or the H heilmannii and mixed infection. The relationship between the spiral organism infection and pathologic change deserves further study.