卵巢上皮性癌组织中细胞周期素D_1的表达

Expression of CyclinD_1 in tissues of human ovarian epithelial carcinoma

目的 :探讨细胞周期素D1(CyclinD1)表达在卵巢上皮性癌发病中的作用。方法 :应用SABC免疫组化技术 ,检测 40例卵巢上皮性癌、12例良性卵巢上皮性肿瘤和 10例正常卵巢组织中CyclinD1的表达 ,并对其表达与卵巢上皮性癌临床分期、组织学分级、组织学类型和生存时间的关系进行探讨。结果 :CyclinD1阳性表达多见于临床期别晚和生存期短的病例组 (P <0 0 5 ) ,低分化者阳性表达高于高分化者 ,Ⅲ级与Ⅱ级、Ⅰ级比较 ,差异有显著性(P <0 0 5 )。结论 :CyclinD1表达与卵巢上皮性癌的临床病理指标有关 ,对估计其进展。

Aim:To explore the potential role of CyclinD 1 expression in the progression of ovarian carcinoma.Methods: Using immunohistochemical staining technique to detect the expression of CyclinD 1 in 40 cases of ovarian epithelial carcinoma, 12 cases of benign ovarian epithelial tumors and 10 cases of normal ovaries The relationship between the expression of CyclinD 1 and 4 parameters: the clinical stage, differential grade, histological type and survival time was analyzed respectively Results: The expressions of CyclinD 1 in cases at poor clinical stage and cases with short survival time were higer than those in cases at good clinical stage and cases with long survival time(P<005); the expression was higher in cases at low differential grade than that in cases at high differential grade, and there was significant difference when comparing grade Ⅲ with grade Ⅱ or grade Ⅰ(P<005).Conclusion: The expression of CyclinD 1 is closely correlated with the clinicopathological parameters of ovarian carcinoma Detection of CyclinD 1 is of some inferential value in estimating the progression and clinical outcome of ovarian epithelial carcinoma