摘要
目的从形态学探讨盐酸哌唑嗪(PZ)对脱交感家兔眼(FSRE)葡萄膜巩膜途径(FU)的作用。方法家兔作单侧颈交感神经节切除术后第14日在手术侧点PZ滴眼液,通过前房内注入异硫氰酸荧光素牛血清白蛋白,PZ点眼后每2 h各处死家兔 2只,于荧光显微镜下观察 FU各部位的荧光强度等级。结果 PZ点眼后 FSRE眼压下降,但降压幅度低于正常家兔眼;点眼后FU各部位的荧光强度均稍强于对侧眼的相应部位,但明显弱于PZ在正常家兔眼的相应部位。结论PZ增加FU排出的作用在FSRE明显减弱,其作用部分依赖于交感神经活性,尚有未通过交感活性的其它机制。
Objective To observe the morphology of the uveoscleral pathway following topical Prazosin(PZ) in rabbit freesympathetic eyes. Methods The one lateral superior cervical ganglionectomy(SCG) were preformed on each rabbit. PZ drops were installed only on the SCG eyes on 14 days Postoperationly. Microamounts of fluorescein isothiocyanate-bovine serum albumin (FITC-BSA ) was infused into anterior chamber of rabbit eyes as the teacer,two rabbits in each group were killed at 2,4,6,8, 10, and 12 h after PZ instillation. Degress of fluorescent intensity of ciliary body, suprachoroidal space, anterior and posterior sclera, and choroid were observed under fluorescence microscopy. Results The IOP of the SCG eyes was lower after installation of PZ. But the reduced extent is below that of normal rabbit eyes; After installation of PZ,the nuorescent intensity of the ciliary body, suprachoroidal space,anterior and posterior sclera,and choroid was less stronger than the control eyes,but fader than at the same area of the normal eyes obviously. Conclusion The outflow effects of PZ drops on increasing uveoscleral pathway were obviously decreased in the SCG eyes. It depends on the activity of sympathetic nerve system partially. Besides,there are other mechanisms.
出处
《眼科研究》
CSCD
北大核心
2001年第1期5-7,共3页
Chinese Ophthalmic Research
基金
国家自然科学基金资助!(基金编号:39370724)
关键词
盐酸哌唑嗪
葡萄膜巩膜途径
脱交感家兔眼
眼压
Prazosin Hydrochloride uveoscleral outflow free-sympathetic rabbit eye intraocular pressure