摘要
目的观察钙离子通道阻滞剂氟桂嗪（ｆｌｕｎａｒｉｚｉｎｅ）在视网膜缺血损伤中的保护作用。方法用ＴＢＡ法测定免眼视网膜缺血再灌注不同时期脂质过氧化代谢产物丙二醛（ＭＤＡ）含量变化，比较实验组、氟桂嗪治疗组的差异。结果实验组、治疗组在缺血再灌注３０，６０，９０ ｍｉｎ时与正常对照组相比ＭＤＡ含量均有显著增加（Ｐ＜０．０１）；氟桂嗪治疗组ＭＤＡ含量在缺血再灌注３０，６０，９０ｍｉｎ３个时间段均明显低于实验组（Ｐ＜０．０１）。结论细胞内Ｃａ２＋超载参与了视网膜组织缺血损伤的病理生理过程。氟桂嗪对急性视网膜缺血损伤具有保护作用。
Objective To observe the protective effects of flunarizine(FZN) in retinal ischemic injury. Methods For' the experimental group and the treated group in ischemic reperfusion different stages, the contents of lipid peroxide metabolim malondialdehyde (MDA) in rabbites' retinal tissues were detected by using TBA. Results The contents of MDA in the experimental and treated groups at 30 min,60 min and 90 min of reperfusion increased remarkably compared with that of the normal control group(P < 0. 01 ). The contents of MDA in the treated group at 30 min,60 min and 90 min of reperfusion were much lower than that of MDA in the experimental group at 30 min,60 min and 90 min of reperfusion respectively(P < 0. 01 ). Conclusion Intracellular calcium overload may be involved in pathophysiologic process of retinal ischemic injury. Flunarizine has the protective effects in retinal ischemic injury.
出处
《眼科研究》
CSCD
北大核心
2001年第1期23-25,共3页
Chinese Ophthalmic Research
