双氯芬酸钠兔眼玻璃体内注射对视网膜电图影响的研究

Studies on the effects of diclofenac sodium intravitreal injection in rabbits on electroretinogram

目的检测不同浓度双氯芬酸钠对实验兔视网膜电图的影响。方法将２８只新西兰白兔随机分为７组。将４００～ １０００ μｇ不同剂量的双氯芬酸钠溶液 ０． １ｍｌ分别注入第 １～７组家兔右眼玻璃体内。左眼为对照组，均在玻璃体注入 ０． １ｍｌ生理盐水。分别在注药后 １，３，７，１４，２１，２８天进行 ＥＲＧ检查。结果当兔眼玻璃体注入的双氯芬酸钠大于或／和等于 ７００ μｇ时，ＥＲＧ检查发现暗适应和明适应 ｂ波波幅明显下降。结论兔眼玻璃体注入的双氯芬酸钠大于或／和等于７００μｇ时，对视网膜有毒性作用。

Objective To detect the electroretinogram changes of rabbits' eyes received by intravitreal injection of diclofenac sodium. Methods 28 rabbits were randomly divided into 7 groups. The right eyes of these rabbits were intravitreal injected diclofenac sodium at different dosage from 400 μg to 1 000 μg in 0. 1ml, respectively. The left eyes of the rabbits as the control received intravitreal injection of 0. 9% salt water. ERG was detected at l, 3, 7, 14, 21, 28 days after injection respectively. Results The b wave amplitudes of light and dark adaptation ERG were significantly reduced when the dosage of diclofenac sodium was more than 700 μg. Conclusion There is toxic effect on the cone and rod systems of retina when the diclofenac sodium's dosage is more than 700 μg.