摘要
目的 比较妊娠高血压综合征肾病综合征型(简称妊高征肾病综合征型)与非肾病综合征型的发病特点及其对母儿影响。方法 收集我院1997年1月～1999年12月重度妊高征123例,诊断为妊高征肾病综合征型20例列为肾病组,非肾病综合征103例列为非肾病组,回顾分析2组发病特点,病情程度,终止妊娠时间,母儿并发症及预后。结果 肾病组发病平均孕周为(32.15±3.48)周,早于非肾病组(34.30±4.57)周(P<0.05);孕期血压,肾病组明显高于非肾病组,平均最高值(14.40/9.38±1.43/1.12)kPa和(13.59/8.76±1.62/1.16)kPa(P<0.05);肾病组胎盘早剥发生率高达25.00％(5/20),而非肾病组仅为0.97％(1/103)(P<0.05);终止妊娠时间分别为(33.80±3.12)周和(36.41±2.98)周,肾病组早于非肾病组(P<0.01);新生儿出生平均体重,肾病组(1 913.75±657.52)g,显著低于非肾病组(2 682.50±826.54)g(P<0.001);肾病组低出生体重儿发生率为90.00％(18/20),围生儿死亡率达20.00％(4/20),非肾病组分别是39.80％(41/103)和4.04％(4/99),显著低于肾病组(P<0.005)。结论 妊高征肾病综合征组较非肾病综合征组孕期发病早,病情重,一旦诊断,应尽早终止妊娠。
Objective To compare the pathogenic characters of preeclampsia with and without nephritic syndrome, and their effect on mothers and infants. Methods 123 cases of preeclampsia (20 with nephritic syndrome as group A and 103 cases without nephritic syndrome as group B) were recruited from January 1997 to December 1999 in our hospital. Pathogenic characters, patient's condition, termination weeks, complications, and prognosis of mothers and infants were analyzed retrospectively. Results The occurrence and termination weeks in group A (32.15 weeks,33. 80 weeks,respectively) were significantly earlier than those of group B(34. 30 weeks, 36. 41 weeks, respectively) (P<0. 05). The mean highest blood pressure (14. 49/9. 38 kPa) and incidance of abruption of placenta (25.00%), low birth weight infant (90.00%) and perinatal mortality (20. 00 %) in group A were higher than those in group B (13. 56/8. 76 kPa, 0. 97 % , 39. 80 % , 4. 04 % , respectively) (P<0. 05). The mean birth weight of newborns in group A was lower than that of group B (1 917. 75 g vs. 2 682. 50 g) (P<0. 05). Conclusions The onset of preeclampsia in patients with nephritic syndrom is earlier than in those without nephritic syndrome, and the symptoms are more serious. Pregnancy should be terminated as earlier as possible after preeclampsia with nephritic syndrome has been diagnosed.
