骨转移癌介入治疗的临床应用

Interventional treatment of bone metastases

目的 :通过对 18例骨转移癌 43次介入治疗结果进行分析 ,探讨采用介入治疗骨转移癌的疗效。方法 :18例骨转移癌行股动脉穿刺插管动脉造影 ,明确肿瘤侵犯不同部位及动脉供血情况。 18例骨转移癌患者共行 43次介入治疗 ,12例行介入动脉内灌注化疗 ,6例介入动脉内灌注化疗并栓塞治疗 ;其中 8例原发灶与骨转移灶同时介入治疗。结果 :治疗后患者疼痛减轻 ,体征改善明显。血管造影肿瘤血管和肿瘤染色明显减少。总有效率 ( CR+PR)为 2 7.8% ,1年生存率为 16 .7% ,中位生存期 7.5个月 ,无严重并发症发生。结论 :采用介入化疗或栓塞术是治疗骨转移癌的一种有效姑息性的方法。

Objective: To evaluate intra arterial infusion chemotherapy and embolization in the treatment of bone metastases. Methods: Angiography of artery was performed in 18 cases (43 procedures) with bone metastases. Once the tumor feeding arteries were identified, intra arterial chemotheraphy and/or embelization was done, which were repeated monthly. Results: The clinical symptoms were markedly relieved in all cases. On following up angiography, tumor's vessel and staining were reduced obviously. The total efficiency was 27.8%, 1 year's survival rate was 16.7%, the median survival time was 7.5 months. No serious complications due to the treatment were recognized. Conclusion: Interventional therapy is safe and effective in palliative treatment for bone metastases.