期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

钾通道开放剂对大鼠缺血性脑损伤的保护作用 被引量：3

The Protect Effect of K^+ Channel Openers (KCOS) on Ischemic Brain Injury in Rat
原文传递
导出
摘要 目的 :探讨K+ 通道开放剂对于缺血性脑损伤的保护作用。方法 :于右大脑中动脉夹闭前 3 0min ,向鼠的侧脑室内注射K+ 通道开放剂 ,并应用生理病理学方法检测脑的缺血性损伤情况。结果 :夹闭后 4h ,实验组与对照组相比 ,其缺血脑组织中MDA浓度明显升高 (P <0 0 5 ) ,而SOD浓度和含水量则明显下降 (P <0 0 5 )。夹闭 3d后 ,电镜下显示用药组产生较轻的病理改变及线粒体变性 (P <0 0 5 )。结论 :本实验显示K+ Aim:To investigate the effects of K + channel openers in ischemic brain injury. Methods:K + channel openers (KCOS) were administered intraventricularly 30 min before the occlusion of right middle cerebral artery, the ischemic damage of brain was measured by histopathological examination. Results:There was a significantly higher MDA concentration ( P <0 05), a significantly lower SOD concentration ( P <0 05) and water content ( P <0 05) 4 h after the occlusion in animals receiving K + channel openers (KCOS). Electronic microscopy study showed a fewer mitochondria degeneration ( P <0 01) on day 3 in animals receiving KCOS. Conclusion:KCOS can prevent neurological damage from ischemic brain injury.
作者 吴安华 李金铭 杨国瑞 王运杰 蔡宝江
机构地区 中国医科大学附属第一医院神经外科 中国医科大学药理教研室 内蒙古赤峰市平庄矿务局总医院脑外科
出处 《中国临床神经科学》 2001年第1期16-17,共2页 Chinese Journal of Clinical Neurosciences
关键词 钾离子通道开放剂 KCOS 超氧化物歧化酶 SOD 丙二醛 MDA 脑缺血 脑保护 大鼠 K + channel openers (KCOS) superoxide dismutase (SOD) malondialdehyde (MDA)
分类号 R743.31 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

  • 1[1]Standen NB, Quayle JM, Davies NW, et al. Hyperpolarization vasodilators active ATP-sensitive K+ channels in arterial smooth musles. Science, 1989;245:177-180
  • 2[2]Heurteaux C, Bertaina V, Widmann C, et al. K+ channel openers prevent global ischemia induced expression of c-fos, c-jun, heat shock protein and amyloid-b protein precussor genes and neuronal death in rat hippocampus.Proc Natl Acad Sci USA, 1993;96:9431-9436
  • 3[3]Heroshio. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 1979;95:351-354
  • 4[4]Stefan M. Involvement of the superoxides anion radical in the autoxidation of pyrogallol and a covenient assay for superoxide dismutase. Eur J Biochem,1974;47:496-500
  • 5[5]Gotoh O, Asano T, Koide T, et al. Ischemic brain edema following occlusion of the middle cerebral artery in the rat. Stroke, 1985;16:101-109
  • 6[6]Hiroyuki K, Tsutomu A, Kyuya K, et al. Sequential cerebral bloodl flow changes in short-term cerebral ischemia in gerbils. Stroke, 1990; 21: 1346-1349
  • 7[7]Goldman MS, Robert, Anderson, et al. Pathophysiological and treatment of focal cerebral ischemia. J Neurosurg,1992;77:169-184

同被引文献41

  • 1龙超良,汪海,肖文彬.吡那地尔对高血压血管重构的影响[J].中国药理学与毒理学杂志,1997,11(1):42-46. 被引量：6
  • 2Choi DW. Ionic dependence of glutamate neurotoxicity in cortical cell culture. J Neurosci, 1987,7 : 369.
  • 3Heron L, virsolvy A, Peyrollier K, et al. Huamn α-endosulfine a possible regulator of a sulfonylurea-sentitive KATP channel: molecular cloning, expression, and biological properties. Proc Nail Acad Sci USA,1998,95:8 387.
  • 4Ye GL, Leng CK, Yung WH, et al. Pre-synaptic effect of the ATP-sensitive potassium channel opener diazoxide or rat substantia nigra pars reticulata neurons. Brain Res, 1997,753(1 ):1.
  • 5Fujita H,Takizawa S, Nanri K,et al. Potassium channel opener reduces entracellular glutamate concentration in rat focal cerebral ischemia Brain Res Bull, 1997,43(4):365.
  • 6Mizuno Y, Changes in superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase actovities and thiobarbituric acid reactive product levels in early stages of development in dystrophic chickens. Exp Neurol. 1984,84( 1 ) :58.
  • 7Duan Meynell AA, Rawson NE, Levin BE. Distribution and phenotype of neurons containing the ATP-sensitive K^+ channel in rat brain. Brain Res,1998,814(1-2) :41.
  • 8Takaba H,Nagao T,Yao H,et al. An ATP-sensitive potassium channel activatorreduces infarct volume in focal cerebral ischemia in rats. Am J Physiol,1997,273(2 Pt 2) :R 583.
  • 9Gribble FM, Tucker SJ, Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J, 1997, 16(6): 1145-1152.
  • 10Quast U. ATP-sensitive K+ channels in the kidney. Naunyn Schmiedebergs. Arch Pharmacol, 1996, 354(3): 213-225.

引证文献3

二级引证文献8

中国临床神经科学
2001年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部