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抑瘤基因NF_2的研究进展 被引量：3

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摘要 介绍抑瘤基因NF2 的突变 ,缺失及其产物Merlin 。
作者 周东 李龄
机构地区 同济医科大学附属同济医院神经外科
出处 《中国临床神经科学》 2001年第1期101-103,共3页 Chinese Journal of Clinical Neurosciences
关键词 肿瘤抑制基因 神经纤维瘤病Ⅱ型 MERLIN NF2基因 基因突变
分类号 R730.23 [医药卫生—肿瘤]
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参考文献16

  • 1[1]Welling DB. Clinical manifestations of umtations in the neurfibromatosis type 2 gene in vestibular schwannomas(acoustic neuromas). Laryngoscope, 1998,108:178-189
  • 2[2]Kluwe L, Maccollin M,Tatagiba M, et al. Phenotypic variabiliy associated with 14 splice-site mutations in the NF2 gene. AM J Med G-enet, 1998,77:228-233
  • 3[3]Lutchman M, Rouleau GA. Neurofibromatosis type 2: a new mechanism of tumor suppression Trends. Neurosci, 1996, 19:373-377
  • 4[4]Rouleau GA, Merel P. Lutchnman M, et al. Alteration in a new gene necoding a putative membrane-organizing protein causes neuro-fibromatosis type2.Nature, 1993,363:515-521
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  • 7[7]Lekanne Deprez RH, Bianchi AB. Grown NA, et al. Frequent NF2 gene transcript mutations in sporadic mentingiomas and vestibular schmwannomas.Am J Hum Genet, 1994,54:1022-1029
  • 8[8]Sainz Jainz J, Figueroa K, Baser ME, et al. High frequency of nonsense mutations in the NF2 gene caused by C to T transsitions in 5CGA condons.Hum Mol Genet , 1995,4:137-139
  • 9[9]Jacoby LB, Maccollin M, Barone R,et al. Frequency and distribution of NF 2mutations in schwannomas. Genes Chromosomes & Cancer, 1996,17:45-55
  • 10[10]Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti, et al. Universal absence of merliin, but not other ERM family members, in schwannmas. Am J Pathol,1997,151:1649-1154

同被引文献26

  • 1严明,陈万涛,何荣根.Ⅱ型神经纤维瘤病分子遗传学研究进展[J].中国口腔颌面外科杂志,2005,3(3):251-254. 被引量：3
  • 2吕静荣,邹静,吴皓.Merlin蛋白在听神经瘤组织中的表达与分布[J].中华耳鼻咽喉头颈外科杂志,2006,41(7):501-505. 被引量：3
  • 3刘树库,许绍发,骆宝剑,刘志东,李福根,韩毅.1380例手术后的非小细胞肺癌的多因素预后分析[J].中国肺癌杂志,2006,9(5):465-468. 被引量：12
  • 4Patronas NJ, Courcoutsakis DN. Intramedullary and spinal canal tumors in patients with neurofibromatosis 2: MR imaging findings and correlation with genotypel. Neuroradiology, 2001,218 : 434- 442.
  • 5Mautner VF, Tatagiba M, Lindenau M, et al. Spinal tumors in patients with neurofibromatosis type 2: MR imaging study of frequency, multiplicity and variety. AJR Am J Roentgenol , 1995, 165:951-955.
  • 6Hoshimaru M, Koyama T , Hashimoto N , et al . Results of microsurgical treatment for intramedullary spinal cord ependymomas : analysis of 36 cases. Neurosurgery , 1999 , 44 : 254-269.
  • 7Ruggieri M, Iannetti P, La Mantia I, et al . Earliest clinical manifestations and natural history of neurofibromatosis type 2 (NF2) in childhood: a study of 24 patients. Neuropediatrics , 2005, 36: 21-34.
  • 8Kaiser-Kupfer MI, Freidlin V, Datiles MB, et al. The association of posterior capsular lens opacities with bilateral acoustic neuromas in patients with neurofibromatosis type 2. Arch Ophthalmol, 1989, 107:541-544.
  • 9Sun B , Wang C , Wang J , et al. MRI feat ures of int ramedullary spinal cord ependymomas. Neuroimaging, 2003, 13:346-351.
  • 10He J, Gu D, Reynolds K, et al. Major causes of death among men and women in China[ J]. N Engl J Med, 2005, 353 (11) :1124-1134.

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中国临床神经科学
2001年 第1期

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